Police have charged Christopher Robert Murray, 20, of 61 Clemson Drive, Aiken, with the death of 21-year-old James Anthony Gibson.
Gibson was found shot to death in his home at 701 Black Snake Road Monday.
Police have also charged an Easley woman in connection with the case.
Beulah Faye Brissey, of 105 Baywood Court, was charged with accessory after the fact to murder.
Murray and Brissey were last seen traveling in a white 1997 Chevrolet Cavalier convertible, according to police.
The car has tree white skull decals across the front windshield and duct tape on the convertible top, they said.
They said Murray is also wanted in Florence on an armed robbery charge.
Gibson was found on his living room floor Monday evening, according to an incident report.
Coroner Kandy Kelley said he died from a gunshot wound.
Police say they consider Murray and Brissey to be armed and dangerous and ask that anyone with information on their whereabouts contact Crimestoppers at (864) 898-KOPS or call 911.
The case is still under investigation.